Jerome Nwachukwu,
Scripps Staff Scientist
Publications
Academic Articles
2025
Native top-down proteomics enables discovery in endocrine-resistant breast cancer
Nature Chemical Biology.
[DOI] 10.1038/s41589-025-01866-8.
2024
Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.04.10.588871.
[PMID] 38645081.
2024
Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu.
Proceedings of the National Academy of Sciences of the United States of America.
121(24)
[DOI] 10.1073/pnas.2321344121.
[PMID] 38830107.
2024
Exploring Biological Targets of Magnolol and Honokiol and their Nature-Inspired Synthetic Derivatives: In Silico Identification and Experimental Validation of Estrogen Receptors.
Journal of natural products.
87(11):2568-2579
[DOI] 10.1021/acs.jnatprod.4c00634.
[PMID] 39526345.
2024
Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enable the Selective Synthesis of Benzestrol Isomers.
Journal of the American Chemical Society.
146(45):30771-30777
[DOI] 10.1021/jacs.4c12857.
[PMID] 39481083.
2023
Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
European journal of medicinal chemistry.
246
[DOI] 10.1016/j.ejmech.2022.115011.
[PMID] 36516582.
2023
Native top-down proteomics reveals EGFR-ERα signaling crosstalk in breast cancer cells dissociates NUTF2 dimers to modulate ERα signaling and cell growth.
Research square.
[DOI] 10.21203/rs.3.rs-3097806/v1.
[PMID] 37546719.
2022
Author Correction: Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Communications Biology.
5(1)
[DOI] 10.1038/s42003-022-04172-4.
[PMID] 36323858.
2022
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Communications Biology.
5(1)
[DOI] 10.1038/s42003-022-03841-8.
[PMID] 36104427.
2022
The SARS-CoV-2 spike protein binds and modulates estrogen receptors.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2022.05.21.492920.
[PMID] 35665018.
2022
The SARS-CoV-2 spike protein binds and modulates estrogen receptors.
Science advances.
8(48)
[DOI] 10.1126/sciadv.add4150.
[PMID] 36449624.
2021
Activation of Crtc2/Creb1 in skeletal muscle enhances weight loss during intermittent fasting.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
35(12)
[DOI] 10.1096/fj.202100171R.
[PMID] 34748223.
2021
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling
Nature Chemical Biology.
17(3):307-316
[DOI] 10.1038/s41589-020-00719-w.
[PMID] 33510451.
2021
Dual-mechanism estrogen receptor inhibitors
Proceedings of the National Academy of Sciences.
118(35)
[DOI] 10.1073/pnas.2101657118.
[PMID] 34452998.
2019
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorganic & medicinal chemistry letters.
29(7):905-911
[DOI] 10.1016/j.bmcl.2019.01.036.
[PMID] 30732944.
2018
Author response: The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
.
[DOI] 10.7554/elife.37161.024.
2018
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
Nature Communications.
9(1)
[DOI] 10.1038/s41467-018-03780-1.
[PMID] 29626214.
2018
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
eLife.
7
[DOI] 10.7554/elife.37161.
2017
Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands.
ACS chemical biology.
12(2):494-503
[DOI] 10.1021/acschembio.6b00918.
[PMID] 28032978.
2017
Full antagonism of the estrogen receptor without a prototypical ligand side chain
Nature Chemical Biology.
13(1):111-118
[DOI] 10.1038/nchembio.2236.
[PMID] 27870835.
2017
Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.
Molecular cell.
65(6):1122-1135.e5
[DOI] 10.1016/j.molcel.2017.02.008.
[PMID] 28306507.
2017
Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor.
Bioorganic & medicinal chemistry letters.
27(2):347-353
[DOI] 10.1016/j.bmcl.2016.11.007.
[PMID] 27919657.
2017
Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell chemical biology.
24(1):35-45
[DOI] 10.1016/j.chembiol.2016.11.014.
[PMID] 28042045.
2017
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic acids research.
45(14):8596-8608
[DOI] 10.1093/nar/gkx509.
[PMID] 28591827.
2016
Predictive features of ligand‐specific signaling through the estrogen receptor
Molecular Systems Biology.
12(4)
[DOI] 10.15252/msb.20156701.
[PMID] 27107013.
2015
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.
Science translational medicine.
7(271)
[DOI] 10.1126/scitranslmed.3010626.
[PMID] 25609169.
2015
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.
Nature communications.
6
[DOI] 10.1038/ncomms9013.
[PMID] 26289479.
2014
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.
The EMBO journal.
33(9):1027-43
[DOI] 10.1002/embj.201386145.
[PMID] 24674967.
2014
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.
eLife.
3
[DOI] 10.7554/eLife.02057.
[PMID] 24771768.
2014
Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.
Journal of medicinal chemistry.
57(8):3532-45
[DOI] 10.1021/jm500268j.
[PMID] 24708493.
2013
Improved crystallographic structures using extensive combinatorial refinement.
Structure (London, England : 1993).
21(11):1923-30
[DOI] 10.1016/j.str.2013.07.025.
[PMID] 24076406.
2013
Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α.
Nature chemical biology.
9(5):326-32
[DOI] 10.1038/nchembio.1214.
[PMID] 23524984.
2013
Thiophene-core estrogen receptor ligands having superagonist activity.
Journal of medicinal chemistry.
56(8):3346-66
[DOI] 10.1021/jm400157e.
[PMID] 23586645.
2012
Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.
Organic & biomolecular chemistry.
10(43):8692-700
[DOI] 10.1039/c2ob26531a.
[PMID] 23033157.
2012
Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.
ChemMedChem.
7(6):1094-100
[DOI] 10.1002/cmdc.201200048.
[PMID] 22517684.
2012
Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.
Journal of medicinal chemistry.
55(5):2324-41
[DOI] 10.1021/jm201556r.
[PMID] 22283328.
2012
Structural mechanisms of allostery and autoinhibition in JNK family kinases.
Structure (London, England : 1993).
20(12):2174-84
[DOI] 10.1016/j.str.2012.09.021.
[PMID] 23142346.
2012
The nuclear receptor signalling scaffold: insights from full-length structures.
The EMBO journal.
31(2):251-3
[DOI] 10.1038/emboj.2011.475.
[PMID] 22252143.
2011
Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.
Molecular and cellular biology.
31(17):3639-52
[DOI] 10.1128/MCB.05429-11.
[PMID] 21730289.
2009
Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells.
Cancer research.
69(7):3140-7
[DOI] 10.1158/0008-5472.CAN-08-3738.
[PMID] 19318562.
2007
The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events.
Cancer research.
67(4):1775-82
[PMID] 17308120.
2007
Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27.
Molecular endocrinology (Baltimore, Md.).
21(12):2864-76
[PMID] 17761951.
2006
First-trimester trophoblast cell model gene response to hypoxia.
American journal of obstetrics and gynecology.
194(3):687-93
[PMID] 16522398.
Contact Details
Phones:
- Business:
- (561) 228-3297
Emails:
- Business:
- jnwachukwu@ufl.edu
Addresses:
- Business Mailing:
-
130 SCRIPPS WAY
JUPITER FL 33458